It exists in two isomersĭifferentiated by the orientation of the hydroxyl group at position 1 (circled) in the glucose unit (seeįigure 1). 2 Isomers of Lactose Lactose is a disaccharide consisting of a galactose and a glucose unit. These sections form the basis for a more detailed understanding of directĬompression lactose. These threeīefore a description of each of these three processes, two introductory sections are included in thisĪrticle, the first dealing with isomers of lactose and the second briefly describing the compression 1 Introduction Lactose is processed in three different ways in order to make it directly compressible. Processing technique influences the properties of the products. This introduction to directly compressible lactose described these three processes, and shows how each Roller drying gives lactose mainly in the anhydrous β-form with excellent compaction properties. Granulation gives irregular agglomerates that flow well and compress well. Spray drying gives spherical agglomerates that exhibit excellent flow and compaction properties.
Inherent compressibility of fine lactose, whilst improving the flow. Goal of the secondary processes that convert lactose into directly compressible grades is to maintain the Lactose monohydrate in a fine form can be compressed into hard tablets, but it exhibits poor flow. One gram dissolves in 5 mL water, in 2.6 mL boiling water very slightly soluble in alcohol insoluble in chloroform, ether. Specific optical rotation +92.6 deg to +83.5 deg (10 minutes) to +69 deg (50 minutes) to 52.3 deg (22 hours, c = 4.5) at 20 ☌/D. Becomes anhydrous at 120 ☌ mp: 201-202 ☌ (rapid heating). Stable in air, but readily absorbs odors. Reduces Fehling's solution|MP: 254 ☌ density: 1.59 g/cu cm at 20 ☌ very soluble in water slightly soluble in ethanol insoluble in ethyl ether, chloroform /beta-D-Lactose/|MP: 201 ☌ (decomposes) density: 1.547 g/cu cm at 20 ☌ very soluble in water insoluble in ethanol, ethyl ether, chloroform, methanol /alpha-lactose monohydrate/|Monoclinic sphenoidal crystals from water. Stable in air|On hydrolysis with 2% H2So4, or with emulsin lactose yields 1 mol d_glucose and 1 mol D-galactose.
D-Glucose,4-O-β-D-galactopyranosyl- Lactose 4-O-β-D-Galactopyranosyl-D-glucose Lactin Lactobiose Milk sugar Saccharum lactin Lactin (carbohydrate) (+)-Lactose Lactose anhydrous Aletobiose Galactinum Osmolactan D-(+)-Lactose Tablettose Fast-flo AHL Zeparox EP Lactose Fast-flo Fast-Flo Lactose Pharmatose 21 Pharmatose 325M Nonpareil 107 Tablettose 70 Lactose anhydride Flowlac 100 Tablettose 80 Super-Tab Pharmatosa DCL 21 Sorbalac 400 DCl 11 Granulac 140M Respitose SV 003 Prismalac Sachelac Spherolac Pharmatose DCL 15 Respitose ML 003 Lactohale 300 Sorbolac 400 Dilactose Lactose Edible 90 SuperTab 21AN Respitose ML 001 Granulac 70 Granulac 140 Lactohale 100 Lactohale 200 Variolac 960 PrenoLakt SuperTab 11SD Respitose ML 006 DCL 15 Inhalac 70 Dairylac 80 Respitose SV 010 Respitose MC 001 LE-PRO LAC 451 Lactose DCL 11 Inhalac 250 Tablettose 100 America Grand Lactose GranuLac FlowLac DuraLacH Hilmar Extra Fine Lactose DCL 21 Hilmar Fine Graind Lactopure Refined Powder Respitose SV 001 Hilmar 5030 Leprino 100 3 3 7 8 20 39 106
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